Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2392823 | 0.86 | HPGD (0.47) | MEN1KMT2ASMN1; SMN2MAPK1TSHR | |
| SCHEMBL30185957 | 0.86 | KMT2A (0.46) | KMT2ASMN1; SMN2 | |
| SCHEMBL1884032 | 0.86 | KMT2A (0.46) | KMT2ASMN1; SMN2 | |
| SCHEMBL8979672 | 0.82 | HPGD (0.42) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL317948 | 0.81 | RAB9A (0.52) | KMT2ASMN1; SMN2NPC1TSHR | |
| SCHEMBL8979697 | 0.80 | MAPK1 (0.46) | PARP1MEN1KMT2ASMN1; SMN2PARP10 | |
| Dodecane SCHEMBL28370737 | 0.78 | PARP1 (0.57) | PARP1MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL8979701 | 0.77 | MKNK1 (0.37) | MEN1KMT2ASMN1; SMN2APAF1RGS12 | |
| SCHEMBL3221521 | 0.75 | TSHR (0.45) | MEN1KMT2ATSHR | |
| SCHEMBL5953069 | 0.75 | DRD3 (0.40) | OPRM1OPRD1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502065-A | TREATING HEADACHES | PFIZER INC. (US) | 1996-03-26 | — | — | US | disclosed |
| EP-0636129-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | Pfizer Limited (GB) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021178-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | PFIZER LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |