Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 9/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | MARK3 | P27448 | 1/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.34 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
| ▸ | HTR1B | P28222 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8979704 | 0.78 | HTR1B (0.55) | HTR6HTR1DHTR1B | |
| SCHEMBL19150272 | 0.78 | HTR6 (0.45) | HTR6EPHX1HTR1DHTR1BL3MBTL1 | |
| SCHEMBL8979664 | 0.78 | HTR6 (0.45) | HTR6EPHX1HTR1DHTR1BL3MBTL1 | |
| SCHEMBL8979744 | 0.77 | GSK3B (0.41) | HTR6PIM1MARK3MAP4K2CAMK2B | |
| SCHEMBL8979734 | 0.74 | HTR6 (0.38) | HTR6HTR1DHTR1B | |
| SCHEMBL19540506 | 0.72 | HTR6 (0.44) | HTR6EPHX1 | |
| SCHEMBL8979689 | 0.72 | HTR6 (0.40) | HTR6EPHX1PIM1MARK3MAP4K2 | |
| SCHEMBL19170911 | 0.71 | HTR6 (0.50) | HTR6L3MBTL1 | |
| SCHEMBL6968008 | 0.70 | HTR1D (0.51) | HTR6SCN9AHTR1DHTR1B | |
| SCHEMBL9545537 | 0.69 | HTR1B (0.57) | HTR6HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502065-A | TREATING HEADACHES | PFIZER INC. (US) | 1996-03-26 | — | — | US | disclosed |
| WO-1993021178-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | PFIZER LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |