Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | HTR1B | P28222 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR1F | P30939 | 2/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | GABRP | O00591 | 1/20 | 0.48 |
| ▸ | GABRD | O14764 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.48 |
| ▸ | GABRE | P78334 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8979706 | 0.90 | HTR6 (0.58) | HTR6HTR2AHTR1AHTR1BHTR2C | |
| SCHEMBL8979675 | 0.83 | HTR6 (0.55) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8699573 | 0.81 | HTR6 (0.64) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8699581 | 0.81 | HTR6 (0.64) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8979844 | 0.79 | HTR6 (0.56) | HTR6HTR2AHTR1AHTR1BHTR2C | |
| SCHEMBL8506642 | 0.78 | HTR6 (0.67) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL12244098 | 0.78 | HTR6 (0.67) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL7375886 | 0.78 | HTR6 (0.67) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL29206564 | 0.78 | HTR6 (0.67) | HTR6HTR2ASLC6A4 | |
| SCHEMBL7375881 | 0.78 | HTR6 (0.67) | HTR6HTR1AHTR1BHTR2CHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502065-A | TREATING HEADACHES | PFIZER INC. (US) | 1996-03-26 | — | — | US | disclosed |
| EP-0636129-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | Pfizer Limited (GB) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021178-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | PFIZER LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |