Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | CES2 | O00748 | 1/20 | 0.57 |
| ▸ | CES1 | P23141 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KMO | O15229 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17790237 | 0.85 | ALDH1A1 (0.61) | ALDH1A1CES2CES1TP53KMT2A | |
| SCHEMBL38656427 | 0.83 | ALDH1A1 (0.68) | ALDH1A1CES2CES1TP53KMT2A | |
| SCHEMBL27570821 | 0.83 | ALDH1A1 (0.68) | ALDH1A1CES2CES1TP53KMT2A | |
| SCHEMBL8921654 | 0.83 | ALDH1A1 (0.68) | ALDH1A1CES2CES1TP53KMT2A | |
| SCHEMBL11153162 | 0.83 | ALDH1A1 (0.57) | ALDH1A1CES2CES1TP53KMT2A | |
| SCHEMBL10806282 | 0.82 | ATM (0.55) | ALDH1A1CES2CES1TP53KMT2A | |
| SCHEMBL4472065 | 0.81 | SMN1; SMN2 (0.58) | ALDH1A1CES1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL23014104 | 0.81 | ALDH1A1 (0.77) | ALDH1A1TP53KMT2ASMN1; SMN2HPGD | |
| SCHEMBL17788611 | 0.81 | ADRB2 (0.58) | ALDH1A1CES2CES1TP53KMT2A | |
| SCHEMBL8298069 | 0.81 | ALDH1A1 (0.70) | ALDH1A1CES2CES1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571822-A | AMINO-2-PHENYL-4-QUINOLONE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-11-05 | — | — | US | disclosed |
| WO-1996010563-A1 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-04-11 | — | — | WO | disclosed |
| EP-0094727-A2 | Substituted heterocyclyl phenylformamidines, processes for their preparation and their pharmaceutical use | ISTITUTO DE ANGELI S.p.A. (IT) | 1983-11-23 | — | — | EP | disclosed |