Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | HPGD | P15428 | 5/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1823896 | 0.85 | KDM4E (0.59) | LMNAKDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL1114965 | 0.83 | KDM4E (0.62) | LMNAKDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL11016850 | 0.83 | ALDH1A1 (0.58) | LMNAKDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL12855956 | 0.83 | KDM4E (0.58) | LMNAKDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL798983 | 0.83 | KMT2A (0.54) | LMNAKDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL13162410 | 0.83 | MEN1 (0.54) | LMNAHPGDMEN1KMT2AGAA | |
| SCHEMBL27822275 | 0.82 | KDM4E (0.56) | LMNAKDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL27523141 | 0.82 | KDM4E (0.56) | LMNAKDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL5943622 | 0.82 | KDM4E (0.56) | LMNAKDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL6105988 | 0.82 | LMNA (0.69) | LMNAKDM4EHPGDHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711286-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.p.A. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004048-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.P.A. (IT) | 1995-02-09 | — | — | WO | disclosed |