Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
| ▸ | HEXA | P06865 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9494868 | 0.83 | PARP1 (0.40) | PARP1PARP2SIRT1MAPTSIRT2 | |
| SCHEMBL8981041 | 0.77 | HEXA (0.38) | PARP1PARP2SIRT1NPC1RAB9A | |
| SCHEMBL6947117 | 0.76 | TSHR (0.41) | PARP1PARP2SIRT1NPC1RAB9A | |
| SCHEMBL12714900 | 0.75 | PARP1 (0.68) | PARP1PARP2ALDH1A1GAALMNA | |
| SCHEMBL8980596 | 0.74 | IMPDH2 (0.37) | MAPTKDM4EGAATDP1LMNA | |
| SCHEMBL12715009 | 0.72 | EZH2 (0.39) | NPC1RAB9AMAPTALDH1A1KDM4E | |
| SCHEMBL12715121 | 0.72 | EZH2 (0.37) | NPC1RAB9AALDH1A1KDM4EMAP3K14 | |
| SCHEMBL9174068 | 0.71 | MEN1 (0.43) | RAB9AMAPTALDH1A1KDM4EATM | |
| SCHEMBL8575685 | 0.71 | CYP19A1 (0.39) | NPC1RAB9AKDM4EHTT | |
| SCHEMBL8368757 | 0.70 | KDM4E (0.35) | PARP1PARP2KDM4EHTTHEXA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711286-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.p.A. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004048-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.P.A. (IT) | 1995-02-09 | — | — | WO | disclosed |