Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8980653 | 0.92 | AGTR1 (0.37) | LMNA | |
| SCHEMBL8980819 | 0.86 | AGTR1 (0.31) | — | |
| SCHEMBL8980570 | 0.86 | LMNA (0.31) | LMNAKMT2A | |
| SCHEMBL8980760 | 0.86 | AGTR1 (0.30) | — | |
| SCHEMBL8980863 | 0.85 | AGTR1 (0.35) | LMNAKMT2AMEN1 | |
| SCHEMBL8980864 | 0.85 | AGTR1 (0.32) | — | |
| SCHEMBL8980859 | 0.85 | AGTR1 (0.32) | — | |
| SCHEMBL8980829 | 0.85 | AGTR1 (0.30) | — | |
| SCHEMBL8981244 | 0.84 | AGTR1 (0.43) | LMNA | |
| SCHEMBL8980999 | 0.83 | AGTR1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5484937-A | ANGIOTENSIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1996-01-16 | — | — | US | disclosed |
| US-5175180-A | Antagonist, antagonism | G. D. SEARLE & CO. (US) | 1992-12-29 | — | — | US | disclosed |
| WO-1992011255-A1 | N-SUBSTITUTED N-(α-TRIAZOLYL-TOLUYL)PYRROLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-07-09 | — | — | WO | disclosed |