Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PRF1 | P14222 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9171003 | 0.91 | MEN1 (0.41) | ALDH1A1PRF1SLC18A3TSHRHTT | |
| SCHEMBL8981302 | 0.87 | ALDH1A1 (0.41) | ALDH1A1PRF1SLC18A3HTTCASP3 | |
| SCHEMBL8980698 | 0.84 | PRMT5 (0.41) | ALDH1A1PRF1SLC18A3CASP3CYP2C9 | |
| SCHEMBL8638816 | 0.84 | ALDH1A1 (0.41) | ALDH1A1SLC18A3TSHRCASP3GAA | |
| SCHEMBL8575685 | 0.82 | CYP19A1 (0.39) | TSHRHTTCYP19A1NPC1 | |
| SCHEMBL9173152 | 0.81 | ALDH1A1 (0.39) | ALDH1A1PRF1HTTCYP3A4MAPT | |
| SCHEMBL9167754 | 0.80 | ALDH1A1 (0.36) | ALDH1A1CYP19A1NPC1SMN1; SMN2 | |
| SCHEMBL9174102 | 0.79 | CYP19A1 (0.39) | CYP19A1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL9174736 | 0.77 | ALDH1A1 (0.41) | ALDH1A1SLC18A3TSHRCASP3CYP3A4 | |
| SCHEMBL8797091 | 0.76 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711286-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.p.A. (IT) | 1996-05-15 | — | — | EP | disclosed |
| EP-0490183-B1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO SPA (IT) | 1995-04-19 | — | — | EP | disclosed |
| WO-1995004048-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.P.A. (IT) | 1995-02-09 | — | — | WO | disclosed |
| US-5189034-A | Vasodilating, antianginal agents | ITALFARMACO S.P.A. (IT) | 1993-02-23 | — | — | US | disclosed |
| EP-0490183-A1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO S.p.A. (IT) | 1992-06-17 | — | — | EP | disclosed |