Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 9/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6436979 | 0.91 | ALDH1A1 (0.36) | ALDH1A1LMNAAGTR1MAOBACHE | |
| SCHEMBL9170026 | 0.86 | ROCK2 (0.40) | ALDH1A1MAOBACHECYP19A1HTR2C | |
| SCHEMBL8638777 | 0.86 | MAOA (0.38) | MAOB | |
| SCHEMBL8641204 | 0.86 | ACHE (0.38) | ALDH1A1ACHE | |
| SCHEMBL9166368 | 0.86 | ACHE (0.32) | ALDH1A1LMNAMAOBACHEROCK2 | |
| SCHEMBL8635637 | 0.85 | ALDH1A1 (0.37) | ALDH1A1MAOBACHEROCK2ROCK1 | |
| SCHEMBL8656492 | 0.83 | ROCK2 (0.37) | MAOBACHEHTR2CROCK2ROCK1 | |
| Sinitrodil SCHEMBL31066546 | 0.83 | TSHR (0.34) | ALDH1A1LMNAAGTR1MAOBKDM4E | |
| Sinitrodil SCHEMBL503115 | 0.83 | TSHR (0.34) | ALDH1A1LMNAAGTR1MAOBKDM4E | |
| SCHEMBL8658972 | 0.82 | SMN1; SMN2 (0.39) | ALDH1A1LMNAKDM4ENPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490183-B1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO SPA (IT) | 1995-04-19 | — | — | EP | claimed |
| US-5189034-A | Vasodilating, antianginal agents | ITALFARMACO S.P.A. (IT) | 1993-02-23 | — | — | US | claimed |
| EP-0490183-A1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO S.p.A. (IT) | 1992-06-17 | — | — | EP | claimed |
| EP-0490183-B1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO SPA (IT) | 1995-04-19 | — | — | EP | disclosed |
| US-5189034-A | Vasodilating, antianginal agents | ITALFARMACO S.P.A. (IT) | 1993-02-23 | — | — | US | disclosed |
| EP-0490183-A1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO S.p.A. (IT) | 1992-06-17 | — | — | EP | disclosed |