SCHEMBL8982009

SCHEMBL8982009

Cc1cc(C)c(C(=O)P(=O)(O[Si](C)(C)C)O[Si](C)(C)C)c(C)c1

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 4/20 0.36
TAS1R1 Q7RTX1 4/20 0.36
TAS1R2 Q8TE23 4/20 0.36
KMT2A Q03164 2/20 0.35
HPGD P15428 2/20 0.35
MEN1 O00255 1/20 0.35
LMNA P02545 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
ALDH1A1 P00352 3/20 0.35
MAPT P10636 1/20 0.33
MAPK1 P28482 1/20 0.33
NPSR1 Q6W5P4 2/20 0.33
CRHR1 P34998 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
GAA P10253 1/20 0.32
KDM4E B2RXH2 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
MCOLN3 Q8TDD5 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6904528 0.79 TAS1R3 (0.39) TAS1R3TAS1R1TAS1R2KMT2AHPGD
SCHEMBL15824267 0.79 TAS1R3 (0.36) TAS1R3TAS1R1TAS1R2KMT2AHPGD
SCHEMBL17493328 0.76 TAS1R3 (0.39) TAS1R3TAS1R1TAS1R2KMT2AHPGD
SCHEMBL9079293 0.75 HPGD (0.38) TAS1R3TAS1R1TAS1R2KMT2AHPGD
SCHEMBL68708 0.75 SMN1; SMN2 (0.41) TAS1R3TAS1R1TAS1R2KMT2AHPGD
SCHEMBL15823753 0.75 TAS1R3 (0.41) TAS1R3TAS1R1TAS1R2KMT2AHPGD
SCHEMBL3195966 0.74 TAS1R3 (0.43) TAS1R3TAS1R1TAS1R2KMT2AHPGD
SCHEMBL8398622 0.72 TAS1R3 (0.42) TAS1R3TAS1R1TAS1R2KMT2AHPGD
SCHEMBL69538 0.72 TAS1R3 (0.42) TAS1R3TAS1R1TAS1R2KMT2AHPGD
SCHEMBL28106244 0.72 TAS1R3 (0.42) TAS1R3TAS1R1TAS1R2KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0487453-B1 Silylated acylphosphinoxide CIBA GEIGY AG (CH) 1996-05-22 EP disclosed
US-5210110-A Photoinitiators CIBA-GEIGY CORPORATION (US) 1993-05-11 US disclosed
EP-0487453-A1 Silylated acylphosphinoxide CIBA-GEIGY AG (CH) 1992-05-27 EP disclosed