SCHEMBL8985074

SCHEMBL8985074

CC(=O)OC(COCCCc1ccc2ccccc2c1)C1=CC(=O)OC1O

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.37
CASP1 P29466 1/20 0.36
CASP3 P42574 1/20 0.36
CASP7 P55210 1/20 0.36
CASP6 P55212 1/20 0.36
HDAC1 Q13547 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
NAAA Q02083 1/20 0.34
SIGMAR1 Q99720 1/20 0.33
TPSAB1 Q15661 1/20 0.33
CES2 O00748 1/20 0.32
ASAH1 Q13510 1/20 0.32
FKBP1A P62942 1/20 0.32
SLC6A2 P23975 1/20 0.31
SLC6A4 P31645 1/20 0.31
SLC6A3 Q01959 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9743200 0.89 CYP1A2 (0.35) CYP1A2CASP1CASP3CASP7CASP6
SCHEMBL8985071 0.87 HDAC1 (0.40) CYP1A2CASP1CASP3CASP7CASP6
SCHEMBL9131369 0.84 CYP1A2 (0.39) CYP1A2CASP1CASP3CASP7CASP6
SCHEMBL9734858 0.83 CYP1A2 (0.38) CYP1A2CASP1CASP3CASP7CASP6
SCHEMBL9734854 0.82 CYP1A2 (0.37) CYP1A2CASP1CASP3CASP7CASP6
SCHEMBL9671162 0.81 CYP1A2 (0.33) CYP1A2CASP1CASP3CASP7CASP6
SCHEMBL9735251 0.81 CYP1A2 (0.35) CYP1A2CASP1CASP3CASP7CASP6
SCHEMBL9735703 0.79 CYP1A2 (0.38) CYP1A2CASP1CASP3CASP7CASP6
SCHEMBL9669974 0.75 NAAA (0.40) NAAA
SCHEMBL9734018 0.74 CYP1A2 (0.38) CYP1A2HDAC1HDAC8NAAASIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5134128-A Immunosuppressive and antiproliferative activity for psoriasis and calcium homeostasis ALLERGAN, INC. (US) 1992-07-28 US claimed
EP-0372941-A2 Anti-inflammatory 5-hydroxy-2-furanones ALLERGAN, INC (US) 1990-06-13 EP claimed
US-5541221-A Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss ALLERGAN (US) 1996-07-30 US disclosed
EP-0637240-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING 3 AND 4-SUBSTITUTED 2(5H)-FURANONES FOR INHIBITING BONE LOSS ALLERGAN, INC. (US) 1995-02-08 EP disclosed
US-5387606-A Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss ALLERGAN, INC. (US) 1995-02-07 US disclosed
US-5268387-A Containing ester or carbamate group ALLERGAN, INC. (US) 1993-12-07 US disclosed
WO-1993021915-A1 PHARMACEUTICAL COMPOSITIONS FOR INHIBITING BONE LOSS CONTAINING 3 AND 4-SUBSTITUTED 2(5H)-FURANONES ALLERGAN, INC. (US) 1993-11-11 WO disclosed
US-5134128-A Immunosuppressive and antiproliferative activity for psoriasis and calcium homeostasis ALLERGAN, INC. (US) 1992-07-28 US disclosed
EP-0372941-A2 Anti-inflammatory 5-hydroxy-2-furanones ALLERGAN, INC (US) 1990-06-13 EP disclosed