Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G6 | O60733 | 2/20 | 0.44 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.44 |
| ▸ | FASN | P49327 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9542709 | 0.75 | CES2 (0.40) | MAOB | |
| SCHEMBL3104384 | 0.74 | CES2 (0.45) | FASNMAOB | |
| SCHEMBL7978253 | 0.74 | PLA2G6 (0.58) | PLA2G6PLA2G4AFASNMAOB | |
| SCHEMBL17760806 | 0.71 | PLA2G6 (0.48) | PLA2G6PLA2G4ASIGMAR1 | |
| SCHEMBL4496886 | 0.70 | CYP3A4 (0.43) | PLA2G6PLA2G4AFASNTAAR1CYP3A4 | |
| SCHEMBL29097002 | 0.70 | PLA2G6 (0.43) | PLA2G6PLA2G4AFASNTAAR1 | |
| SCHEMBL7986994 | 0.70 | PLA2G6 (0.47) | PLA2G6PLA2G4AFASN | |
| SCHEMBL4663260 | 0.70 | CYP3A4 (0.52) | PLA2G6PLA2G4AFASNCYP3A4 | |
| SCHEMBL11138811 | 0.67 | FASN (0.58) | PLA2G6PLA2G4AFASNCYP3A4 | |
| SCHEMBL19540531 | 0.67 | FASN (0.45) | PLA2G6PLA2G4AFASNTAAR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541221-A | Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss | ALLERGAN (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0637240-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 3 AND 4-SUBSTITUTED 2(5H)-FURANONES FOR INHIBITING BONE LOSS | ALLERGAN, INC. (US) | 1995-02-08 | — | — | EP | disclosed |
| US-5387606-A | Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss | ALLERGAN, INC. (US) | 1995-02-07 | — | — | US | disclosed |
| US-5268387-A | Containing ester or carbamate group | ALLERGAN, INC. (US) | 1993-12-07 | — | — | US | disclosed |
| WO-1993021915-A1 | PHARMACEUTICAL COMPOSITIONS FOR INHIBITING BONE LOSS CONTAINING 3 AND 4-SUBSTITUTED 2(5H)-FURANONES | ALLERGAN, INC. (US) | 1993-11-11 | — | — | WO | disclosed |