Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.43 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985280 | 0.93 | PTGS2 (0.45) | PTGS2MAPK14PTGS1KDM4EMT-CO1 | |
| SCHEMBL8985538 | 0.90 | PTGS1 (0.51) | PTGS2MAPK14PTGS1KDM4EMT-CO1 | |
| Hydrochloric Acid SCHEMBL8985440 | 0.89 | PTGS1 (0.50) | PTGS2MAPK14PTGS1KDM4EMT-CO1 | |
| Hydrochloric Acid SCHEMBL8985503 | 0.89 | EP300 (0.44) | PTGS2MAPK14PTGS1EP300 | |
| SCHEMBL8985433 | 0.88 | PTGS2 (0.42) | PTGS2MAPK14PTGS1KDM4EMT-CO1 | |
| Hydrochloric Acid SCHEMBL8985309 | 0.87 | PTGS2 (0.67) | PTGS2PTGS1KDM4EMT-CO1MT-CO2 | |
| Hydrochloric Acid SCHEMBL8985517 | 0.87 | PTGS2 (0.44) | PTGS2MAPK14PTGS1KDM4EMT-CO1 | |
| Hydrochloric Acid SCHEMBL8985525 | 0.86 | PTGS2 (0.54) | PTGS2MAPK14PTGS1KDM4EMT-CO1 | |
| SCHEMBL8985500 | 0.85 | PTGS2 (0.50) | PTGS2MAPK14PTGS1KDM4EMT-CO1 | |
| SCHEMBL8985341 | 0.81 | EP300 (0.41) | PTGS2MAPK14PTGS1EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571810-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, COLLAGEN DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-05 | — | — | US | disclosed |
| EP-0593761-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |
| WO-1991019708-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-26 | — | — | WO | disclosed |