⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL898594 | 1.00 | — | — | |
| SCHEMBL12663837 | 0.83 | KDM4E (0.32) | — | |
| SCHEMBL899392 | 0.83 | USP2 (0.35) | — | |
| SCHEMBL899390 | 0.83 | USP2 (0.35) | — | |
| SCHEMBL899389 | 0.83 | USP2 (0.35) | — | |
| SCHEMBL899156 | 0.80 | MEN1 (0.44) | — | |
| SCHEMBL16835486 | 0.74 | DDB1 (0.31) | — | |
| SCHEMBL4052256 | 0.72 | CYP2D6 (0.31) | — | |
| SCHEMBL4052259 | 0.72 | CYP2D6 (0.31) | — | |
| SCHEMBL1622835 | 0.69 | SMARCA4 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230405002-A1 | COMBINATIONS OF DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS AND ACETYL-COA CARBOXYLASE INHIBITOR | PFIZER INC. (US) | 2023-12-21 | — | — | US | disclosed |
| US-20230322777-A1 | N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors | PFIZER INC. (US) | 2023-10-12 | — | — | US | disclosed |
| US-20230218616-A1 | Combinations for Treatment of NAFLD/NASH and Related Diseases | PFIZER INC. (US) | 2023-07-13 | — | — | US | disclosed |
| US-11673890-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2023-06-13 | — | — | US | disclosed |
| EP-3713942-B1 | CRYSTALLINE 2-AMINO-2-(HYDROXYMETHYL)PROPANE-1,3-DIOL SALT OF 4-(4-(1-ISOPROPYL-7-OXO-1,4,6,7-TETRAHYDROSPIRO[INDAZOLE-5,4'-PIPERIDINE]-1'-CARBONYL)-6-METHOXYPYRIDIN-2-YL)BENZOIC ACID | PFIZER (US) | 2023-03-08 | — | — | EP | disclosed |
| EP-4110395-A1 | COMBINATIONS FOR TREATMENT OF NAFLD/NASH AND RELATED DISEASES | Pfizer Inc. (US) | 2023-01-04 | — | — | EP | disclosed |
| US-20220387402-A1 | COMBINATIONS COMPRISING BENZODIOXOL AS GLP-1R AGONISTS FOR USE IN THE TREATMENT OF NASH/NAFLD AND RELATED DISEASES | PFIZER INC. (US) | 2022-12-08 | — | — | US | disclosed |
| US-11325909-B2 | Crystalline 2-amino-2-(hydroxymethyl)propane-1,3-diol salt of 4-(4-(1-isopropyl-7-OXO-1,4,6,7-tetrahydrospiro[indazole-5,4′-piperidine]-1′-carbonyl)-6-methoxypryridin-2-YL)benzoic acid | PFIZER INC. (US) | 2022-05-10 | — | — | US | disclosed |
| US-11254660-B2 | Combinations for treatment of NASH/NAFLD and related diseases | PFIZER INC. (US) | 2022-02-22 | — | — | US | disclosed |
| US-20220023299-A1 | Combinations For Treatment Of NASH/NAFLD And Related Diseases | PFIZER INC. (US) | 2022-01-27 | — | — | US | disclosed |
| US-9908883-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2018-03-06 | — | — | US | disclosed |
| US-20160347752-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2016-12-01 | — | — | US | disclosed |
| EP-2621493-B1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER (US) | 2016-08-17 | — | — | EP | disclosed |
| US-20150376185-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2015-12-31 | — | — | US | disclosed |
| US-9145416-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2015-09-29 | — | — | US | disclosed |
| US-20150011470-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2015-01-08 | — | — | US | disclosed |
| US-8859577-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2014-10-14 | — | — | US | disclosed |
| EP-2621493-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | Pfizer Inc (US) | 2013-08-07 | — | — | EP | disclosed |
| US-20130190334-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2013-07-25 | — | — | US | disclosed |
| WO-2012042433-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2012-04-05 | — | — | WO | disclosed |