SCHEMBL16835486

SCHEMBL16835486

O=C1C=CC2(CCN(C(=O)O)CC2)C1

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 1/20 0.31
CRBN Q96SW2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16612260 0.73 USP2 (0.32)
SCHEMBL361233 0.71 SIGMAR1 (0.37) DDB1CRBN
SCHEMBL30617292 0.71 ALDH1A1 (0.30)
SCHEMBL4738222 0.68
SCHEMBL15655085 0.67 USP2 (0.36)
Hydrochloric Acid SCHEMBL7260312 0.66 NEK2 (0.31)
SCHEMBL2435817 0.66 GABRD (0.31)
SCHEMBL16914420 0.64 CRBN (0.33) DDB1CRBN
SCHEMBL7101802 0.64 CRBN (0.36) DDB1CRBN
SCHEMBL21961916 0.64 HDAC3 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016190847-A1 SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE CALITOR SCIENCES, LLC (US) 2016-12-01 WO disclosed
WO-2015094803-A1 SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE CALITOR SCIENCES, LLC (US) 2015-06-25 WO disclosed