SCHEMBL8986399

SCHEMBL8986399

N#Cc1cc(C(F)(F)F)cnc1OCC(=O)O

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 7/20 0.45
AGBL2 Q5U5Z8 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
TRPM8 Q7Z2W7 1/20 0.41
KDM4E B2RXH2 2/20 0.39
GLA P06280 1/20 0.39
ACACB O00763 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
RECQL P46063 1/20 0.39
FFAR1 O14842 1/20 0.39
MRGPRX4 Q96LA9 1/20 0.39
HPGD P15428 1/20 0.39
PKM P14618 1/20 0.38
HTT P42858 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL20595183 0.81 TRPM8 (0.38) AGBL2SMN1; SMN2TRPM8KDM4EGLA
SCHEMBL28354395 0.79 ACACB (0.37) AGBL2SMN1; SMN2TRPM8KDM4EGLA
SCHEMBL22809638 0.77 CYP11B1 (0.39) SMN1; SMN2TRPM8KDM4EACACBCYP1A2
SCHEMBL10460598 0.76 CYP1A2 (0.40) KDM4EACACBCYP1A2CYP2C19HPGD
SCHEMBL4594851 0.76 PTGDR2 (0.65) PTGDR2
SCHEMBL28882909 0.74 ACACB (0.40) AGBL2SMN1; SMN2TRPM8KDM4EACACB
SCHEMBL28999026 0.74 PDK2 (0.40) ACACB
SCHEMBL5549663 0.71 MAPK1 (0.44) PTGDR2AGBL2SMN1; SMN2TRPM8KDM4E
SCHEMBL4766176 0.71 CYP11B1 (0.42) AGBL2SMN1; SMN2TRPM8KDM4EPKM
SCHEMBL10698723 0.70 PTGDR2 (0.41) PTGDR2SMN1; SMN2KDM4ECYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0441457-B1 Preparation of higher alkyl esters of carboxylic acids DOWELANCO (US) 1996-06-05 EP disclosed
EP-0441457-A2 Preparation of higher alkyl esters of carboxylic acids DOWELANCO (US) 1991-08-14 EP disclosed