Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 5/20 | 0.55 |
| ▸ | PTPRC | P08575 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9522268 | 0.85 | ALDH1A1 (0.49) | PIK3C3PTPRCKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6757588 | 0.83 | PTGS2 (0.55) | PTPRCKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8987394 | 0.78 | PIK3C3 (0.64) | PIK3C3KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL11959778 | 0.74 | SMN1; SMN2 (0.49) | KDM4EALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL11959774 | 0.73 | PDE10A (0.44) | PTPRCKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3329851 | 0.73 | PIM1 (0.65) | PIK3C3KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL13567347 | 0.73 | ALDH1A1 (0.52) | KDM4EALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL3570396 | 0.73 | PTPRC (0.50) | PTPRCKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL11959776 | 0.72 | ERN1 (0.51) | KDM4EALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL11959785 | 0.71 | ERN1 (0.43) | PTPRCALDH1A1SMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5492915-A | ANTIINFLAMMATORY AGENTS | RHONE-POULENC RORER S.A. (FR) | 1996-02-20 | — | — | US | disclosed |
| US-5366982-A | Antiinflammatory agents or antihistamines | RHONE-POULENC RORER S.A. (FR) | 1994-11-22 | — | — | US | disclosed |
| EP-0540604-A1 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | Aventis Pharma S.A. (FR) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001675-A2 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | RHONE-POULENC RORER S.A. (FR) | 1992-02-06 | — | — | WO | disclosed |