Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 12/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ACACA | Q13085 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8987123 | 0.89 | LTB4R (0.64) | LTB4RKDM4EMAPTKMT2AMEN1 | |
| SCHEMBL8987008 | 0.82 | KDM4E (0.50) | LTB4RKDM4EMAPTKMT2AMEN1 | |
| SCHEMBL8987177 | 0.81 | LTB4R (0.82) | LTB4R | |
| SCHEMBL8986973 | 0.80 | LTB4R (0.55) | LTB4RMAPTKMT2AMEN1ACACA | |
| SCHEMBL11029680 | 0.79 | LTB4R (0.39) | LTB4RKDM4EMAPTKMT2AMEN1 | |
| SCHEMBL8987393 | 0.76 | LTB4R (0.83) | LTB4R | |
| SCHEMBL8987191 | 0.75 | LTB4R (0.49) | LTB4RKDM4EMAPTKMT2AMEN1 | |
| SCHEMBL8987327 | 0.75 | LTB4R (0.85) | LTB4RACACA | |
| SCHEMBL8987282 | 0.75 | LTB4R (0.83) | LTB4R | |
| SCHEMBL8987258 | 0.75 | LTB4R (0.71) | LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5492915-A | ANTIINFLAMMATORY AGENTS | RHONE-POULENC RORER S.A. (FR) | 1996-02-20 | — | — | US | disclosed |
| US-5366982-A | Antiinflammatory agents or antihistamines | RHONE-POULENC RORER S.A. (FR) | 1994-11-22 | — | — | US | disclosed |
| EP-0540604-A1 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | Aventis Pharma S.A. (FR) | 1993-05-12 | — | — | EP | disclosed |
| EP-0224173-B1 | STEROIDAL GLYCOLIPIDS AS HOST RESISTANCE STIMULATORS | MERCK & CO. INC. (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992001675-A2 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | RHONE-POULENC RORER S.A. (FR) | 1992-02-06 | — | — | WO | disclosed |