Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ACACA | Q13085 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PRNP | P04156 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8987191 | 0.84 | LTB4R (0.49) | KDM4ELTB4RMAPTKMT2AMEN1 | |
| SCHEMBL8987143 | 0.82 | LTB4R (0.54) | KDM4ELTB4RMAPTKMT2AMEN1 | |
| SCHEMBL8987123 | 0.79 | LTB4R (0.64) | KDM4ELTB4RMAPTKMT2AMEN1 | |
| SCHEMBL20545180 | 0.72 | HDAC1 (0.65) | KDM4ELTB4RKMT2AMEN1ALDH1A1 | |
| SCHEMBL12685572 | 0.72 | HDAC1 (0.65) | KDM4ELTB4RKMT2AMEN1ALDH1A1 | |
| SCHEMBL20545187 | 0.72 | ALDH1A1 (0.56) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL20544596 | 0.71 | HDAC1 (0.62) | KDM4EKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL432515 | 0.71 | ALDH1A1 (0.57) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL20545001 | 0.70 | HTT (0.65) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL20545268 | 0.70 | LMNA (0.65) | KDM4EMAPTKMT2ANPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5492915-A | ANTIINFLAMMATORY AGENTS | RHONE-POULENC RORER S.A. (FR) | 1996-02-20 | — | — | US | disclosed |
| US-5366982-A | Antiinflammatory agents or antihistamines | RHONE-POULENC RORER S.A. (FR) | 1994-11-22 | — | — | US | disclosed |
| EP-0540604-A1 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | Aventis Pharma S.A. (FR) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001675-A2 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | RHONE-POULENC RORER S.A. (FR) | 1992-02-06 | — | — | WO | disclosed |