Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 19/20 | 0.65 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8987246 | 0.86 | LTB4R (0.65) | LTB4RLTB4R2 | |
| SCHEMBL8987236 | 0.82 | LTB4R (0.67) | LTB4RLTB4R2ADORA3ADORA2AADORA1 | |
| SCHEMBL6759178 | 0.81 | LTB4R (0.79) | LTB4RADORA3ADORA2AADORA1 | |
| SCHEMBL8987320 | 0.79 | LTB4R (1.00) | LTB4R | |
| SCHEMBL8987214 | 0.79 | LTB4R (0.72) | LTB4RADORA3ADORA2AADORA1 | |
| SCHEMBL6759665 | 0.77 | LTB4R (0.70) | LTB4RADORA3ADORA2AADORA1 | |
| SCHEMBL6762408 | 0.75 | LTB4R (0.75) | LTB4RADORA3ADORA2AADORA1 | |
| SCHEMBL8987001 | 0.74 | LTB4R (0.79) | LTB4R | |
| SCHEMBL8987047 | 0.74 | LTB4R (1.00) | LTB4R | |
| SCHEMBL6757553 | 0.74 | LTB4R (1.00) | LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5492915-A | ANTIINFLAMMATORY AGENTS | RHONE-POULENC RORER S.A. (FR) | 1996-02-20 | — | — | US | disclosed |
| US-5366982-A | Antiinflammatory agents or antihistamines | RHONE-POULENC RORER S.A. (FR) | 1994-11-22 | — | — | US | disclosed |
| EP-0540604-A1 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | Aventis Pharma S.A. (FR) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001675-A2 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | RHONE-POULENC RORER S.A. (FR) | 1992-02-06 | — | — | WO | disclosed |