Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.39 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.39 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8835619 | 0.83 | KMT2A (0.43) | ALDH1A1SMN1; SMN2MEN1KMT2ATUBB4A | |
| SCHEMBL8835333 | 0.81 | TUBB4A (0.39) | ALDH1A1SMN1; SMN2MEN1KMT2ATUBB4A | |
| SCHEMBL8540489 | 0.78 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MEN1KMT2ATUBB4A | |
| SCHEMBL8835336 | 0.76 | TUBB4A (0.41) | ALDH1A1SMN1; SMN2MEN1KMT2ATUBB4A | |
| SCHEMBL8542139 | 0.65 | MDM2 (0.45) | ALDH1A1LMNATP53MDM2MAPT | |
| SCHEMBL4342125 | 0.64 | GRIN1 (0.55) | MEN1KMT2ALMNACYP1A2MAPK1 | |
| SCHEMBL8119869 | 0.63 | ALDH1A1 (0.46) | ALDH1A1HPGDCYP1A2XBP1CYP2C19 | |
| SCHEMBL25412633 | 0.62 | ALDH1A1 (0.63) | ALDH1A1MEN1KMT2ALMNAHPGD | |
| SCHEMBL4341044 | 0.62 | CYP1A2 (0.49) | ALDH1A1MEN1KMT2ALMNAHPGD | |
| SCHEMBL27488159 | 0.62 | CYP2D6 (0.51) | ALDH1A1SMN1; SMN2KMT2ALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491153-A | 3-amidoindolyl derivative | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| US-5189054-A | 3-amidoindolyl derivatives and pharmaceutical compositions thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0483881-A1 | 3-Amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1992-05-06 | — | — | EP | disclosed |