SCHEMBL8987485

SCHEMBL8987485

COc1cc(OC)cc(-c2cc(-c3ccccc3)[nH]c(=O)c2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.51
HPGD P15428 4/20 0.51
KDM4E B2RXH2 5/20 0.50
CYP1A1 P04798 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP2E1 P05181 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2C8 P10632 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2A6 P11509 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP4B1 P13584 1/20 0.50
CYP2B6 P20813 1/20 0.50
CYP3A5 P20815 1/20 0.50
CYP2A7 P20853 1/20 0.50
CYP3A7 P24462 1/20 0.50
CYP2F1 P24903 1/20 0.50
CYP2C18 P33260 1/20 0.50
CYP2C19 P33261 1/20 0.50
CYP2J2 P51589 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8800017 0.91 GAA (0.55) ALDH1A1HPGDKDM4ECYP1A1CYP1A2
SCHEMBL8987032 0.89 KDM4E (0.59) ALDH1A1HPGDKDM4ESMN1; SMN2MEN1
SCHEMBL8986985 0.89 KDM4E (0.59) ALDH1A1HPGDKDM4ESMN1; SMN2MEN1
SCHEMBL8987301 0.88 GAA (0.59) ALDH1A1HPGDKDM4ESMN1; SMN2GAA
SCHEMBL6756097 0.82 TAS2R38 (0.60) ALDH1A1HPGDKDM4ESMN1; SMN2NPC1
SCHEMBL8986959 0.81 ALDH1A1 (0.66) ALDH1A1HPGDKDM4ESMN1; SMN2MEN1
SCHEMBL8987316 0.80 KDM4E (0.51) ALDH1A1HPGDKDM4ESMN1; SMN2MEN1
SCHEMBL8799713 0.77 HPGD (0.51) ALDH1A1HPGDKDM4ECYP1A2CYP3A4
SCHEMBL8987066 0.77 HPGD (0.51) ALDH1A1HPGDKDM4ECYP1A2CYP3A4
SCHEMBL2407878 0.76 CYP1A1 (0.74) ALDH1A1KDM4ECYP1A1CYP1A2CYP2E1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5492915-A ANTIINFLAMMATORY AGENTS RHONE-POULENC RORER S.A. (FR) 1996-02-20 US disclosed
US-5366982-A Antiinflammatory agents or antihistamines RHONE-POULENC RORER S.A. (FR) 1994-11-22 US disclosed
EP-0540604-A1 SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS Aventis Pharma S.A. (FR) 1993-05-12 EP disclosed
WO-1992001675-A2 SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS RHONE-POULENC RORER S.A. (FR) 1992-02-06 WO disclosed