Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 2/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL149999 | 0.83 | SIGMAR1 (0.59) | PYCR1TMEM97SIGMAR1TSHR | |
| SCHEMBL8987611 | 0.83 | NPC1 (0.42) | PYCR1DPP7 | |
| SCHEMBL9131306 | 0.79 | TMEM97 (0.56) | PYCR1TMEM97SIGMAR1KDM4ETSHR | |
| SCHEMBL11932509 | 0.78 | SIGMAR1 (0.52) | PYCR1TMEM97SIGMAR1KDM4ETSHR | |
| SCHEMBL31612490 | 0.77 | SIGMAR1 (0.55) | PYCR1TMEM97SIGMAR1KDM4ETSHR | |
| SCHEMBL9266697 | 0.76 | LSS (0.44) | TMEM97SIGMAR1 | |
| SCHEMBL17917694 | 0.76 | SIGMAR1 (0.54) | PYCR1TMEM97SIGMAR1KDM4ETSHR | |
| SCHEMBL7855920 | 0.75 | SIGMAR1 (0.50) | PYCR1TMEM97SIGMAR1KDM4ETSHR | |
| SCHEMBL18532755 | 0.75 | PYCR1 (0.67) | PYCR1TMEM97SIGMAR1KDM4ETSHR | |
| SCHEMBL8987565 | 0.75 | KCNH2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527955-A | AGONIST OF GAMMA AMINOBUTYRIC ACID | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-06-18 | — | — | US | disclosed |
| EP-0345068-B1 | Agonist of gamma-aminobutyric acid | WYETH JOHN & BROTHER LTD (GB) | 1995-03-15 | — | — | EP | disclosed |
| US-5321047-A | Antidepressant | JOHN WYETH & BROTHER, LIMITED (GB) | 1994-06-14 | — | — | US | disclosed |
| EP-0345068-A2 | Agonist of gamma-aminobutyric acid | JOHN WYETH & BROTHER LIMITED (GB) | 1989-12-06 | — | — | EP | disclosed |