Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrogen Peroxide SCHEMBL8452315 | 0.93 | PARP1 (0.62) | PARP1ERCC5FEN1KDM4EKMT2A | |
| SCHEMBL4370629 | 0.91 | PARP1 (0.64) | PARP1ERCC5FEN1KDM4EKMT2A | |
| SCHEMBL29351761 | 0.91 | PARP1 (0.64) | PARP1ERCC5FEN1KDM4EKMT2A | |
| SCHEMBL1259 | 0.91 | PARP1 (0.64) | PARP1ERCC5FEN1KDM4EKMT2A | |
| SCHEMBL10664817 | 0.89 | PARP1 (0.58) | PARP1ERCC5FEN1KDM4EKMT2A | |
| SCHEMBL11628321 | 0.89 | PARP1 (0.58) | PARP1ERCC5FEN1KDM4EKMT2A | |
| SCHEMBL11105533 | 0.89 | PARP1 (0.62) | PARP1ERCC5FEN1KDM4EKMT2A | |
| SCHEMBL11613703 | 0.89 | PARP1 (0.62) | PARP1ERCC5FEN1KDM4EKMT2A | |
| SCHEMBL31245780 | 0.89 | PARP1 (0.62) | PARP1ERCC5FEN1KDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL8503466 | 0.89 | PARP1 (0.62) | PARP1ERCC5FEN1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119638641-A | Ferrous ion and viscosity dual-response fluorescent probe in parkinsonism model and preparation method and application thereof | 山西医科大学 | 2025-03-18 | — | — | CN | claimed |
| CN-119638641-A | Ferrous ion and viscosity dual-response fluorescent probe in parkinsonism model and preparation method and application thereof | 山西医科大学 | 2025-03-18 | — | — | CN | disclosed |
| US-5585501-A | Method for the reduction of allyl alcohols | SHIONOGI & CO., LTD. (JP) | 1996-12-17 | — | — | US | disclosed |