Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.33 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.33 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.33 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.33 |
| ▸ | DUT | P33316 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4231518 | 0.80 | CRBN (0.45) | CRBNDDB1ALDH1A1LMNAPKM | |
| SCHEMBL24755086 | 0.80 | CRBN (0.50) | CRBNDDB1ALDH1A1LMNAPKM | |
| SCHEMBL27581645 | 0.77 | CRBN (0.50) | CRBNDDB1ALDH1A1LMNAPKM | |
| SCHEMBL2976955 | 0.75 | CRBN (0.48) | CRBNDDB1ALDH1A1LMNAPKM | |
| SCHEMBL28132697 | 0.73 | CRBN (0.47) | CRBNDDB1ALDH1A1LMNAPKM | |
| SCHEMBL7056290 | 0.73 | CRBN (0.52) | CRBNDDB1ALDH1A1LMNAPKM | |
| SCHEMBL1398237 | 0.73 | CRBN (0.42) | CRBNDDB1ALDH1A1LMNAPKM | |
| SCHEMBL20365469 | 0.71 | CRBN (0.44) | CRBNDDB1ALDH1A1LMNAPKM | |
| SCHEMBL913153 | 0.68 | TYMP (0.51) | CRBNDDB1LMNAPKMDUT | |
| SCHEMBL422813 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0719271-A1 | 5-(1-FLUORO-VINYL)-1H-PYRIMIDINE-2,4-DIONE DERIVATIVES USEFUL AS ANTINEOPLASTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-03 | — | — | EP | disclosed |
| WO-1995007917-A1 | 5-(1-FLUORO-VINYL)-1H-PYRIMIDINE-2,4-DIONE DERIVATIVES USEFUL AS ANTINEOPLASTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-03-23 | — | — | WO | disclosed |