Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8988016 | 0.83 | CYP19A1 (0.40) | SHBGSTSMAPT | |
| SCHEMBL8987956 | 0.73 | SHBG (0.38) | SHBGSTSPTPN1MEN1MAPT | |
| SCHEMBL4816847 | 0.71 | ESR1 (0.37) | SHBGSTSMEN1MAPTMAPK1 | |
| SCHEMBL8518605 | 0.70 | ESR1 (0.38) | SHBGPTPN1 | |
| SCHEMBL11981697 | 0.70 | SHBG (0.62) | SHBGSTSMEN1MAPTKMT2A | |
| SCHEMBL17296147 | 0.69 | ESR1 (0.37) | SHBGPTPN1 | |
| SCHEMBL5851260 | 0.69 | SHBG (0.61) | SHBGSTSMEN1MAPTMAPK1 | |
| SCHEMBL6130909 | 0.67 | STS (0.48) | SHBGSTSKMT2A | |
| SCHEMBL8969620 | 0.67 | CYP19A1 (0.54) | SHBGSTSMAPT | |
| SCHEMBL4588126 | 0.66 | SHBG (0.56) | SHBGSTSMEN1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0719276-A1 | ORALLY ACTIVE DERIVATIVES OF 1,3,5(10)-ESTRATRIENE | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1996-07-03 | — | — | EP | disclosed |