Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6652679 | 0.83 | CFTR (0.52) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL8989205 | 0.81 | TDP2 (0.44) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL8989105 | 0.79 | KDM4E (0.41) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL8989227 | 0.78 | ALDH1A1 (0.41) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL8989175 | 0.76 | PDE2A (0.40) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL18002981 | 0.70 | CDK2 (0.40) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL8989158 | 0.69 | PPARD (0.47) | KDM4EALDH1A1MAPTLMNAPIK3CD | |
| SCHEMBL6631450 | 0.68 | KMT2A (0.49) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL16398903 | 0.67 | NPC1 (0.48) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL18003589 | 0.67 | KDM4E (0.42) | KDM4EALDH1A1SIGMAR1TDP2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545645-A | Heterocyclic derivatives in the treatment of ischaemia and related diseases | SYNTEX PHARMACEUTICALS, LIMITED (GB) | 1996-08-13 | — | — | US | disclosed |
| US-5428037-A | Piperazine derivatives; calcium and sodium channel antagonists | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1995-06-27 | — | — | US | disclosed |