Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329614 | 0.75 | KMT2A (0.44) | KMT2AALDH1A1HPGDCCNB2CDK1 | |
| SCHEMBL28630613 | 0.75 | KMT2A (0.52) | KMT2AALDH1A1HPGDCCNB2CDK1 | |
| SCHEMBL1156785 | 0.74 | ALDH1A1 (0.43) | ALDH1A1HPGDLMNAPTGS2BRD4 | |
| SCHEMBL2214810 | 0.71 | NOTUM (0.50) | KMT2AALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL2518213 | 0.70 | ALDH1A1 (0.57) | KMT2AALDH1A1LMNANPC1RAB9A | |
| SCHEMBL1156583 | 0.70 | PTGS2 (0.55) | LMNAPTGS2PTGS1MAPTSMN1; SMN2 | |
| SCHEMBL25062167 | 0.69 | KMT2A (0.46) | KMT2AALDH1A1HPGDCCNB2CDK1 | |
| SCHEMBL25062987 | 0.69 | KMT2A (0.46) | KMT2AALDH1A1HPGDCCNB2CDK1 | |
| SCHEMBL3260887 | 0.69 | BRD4 (0.47) | KMT2AALDH1A1HPGDTSHRLMNA | |
| SCHEMBL11436206 | 0.69 | ALDH1A1 (0.56) | KMT2AALDH1A1HPGDCCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545645-A | Heterocyclic derivatives in the treatment of ischaemia and related diseases | SYNTEX PHARMACEUTICALS, LIMITED (GB) | 1996-08-13 | — | — | US | disclosed |
| US-5428037-A | Piperazine derivatives; calcium and sodium channel antagonists | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1995-06-27 | — | — | US | disclosed |