Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8989163 | 1.00 | HTT (0.50) | HTTTGM2SIRT2SIRT1FOLH1 | |
| SCHEMBL8989010 | 0.91 | HTT (0.53) | HTTTGM2SIRT2SIRT1FOLH1 | |
| SCHEMBL8989003 | 0.91 | HTT (0.53) | HTTTGM2SIRT2SIRT1FOLH1 | |
| SCHEMBL9857311 | 0.90 | HTT (0.54) | HTTTGM2SIRT2SIRT1FOLH1 | |
| SCHEMBL9857308 | 0.90 | HTT (0.54) | HTTTGM2SIRT2SIRT1FOLH1 | |
| SCHEMBL8989021 | 0.85 | HTT (0.44) | HTTTGM2SIRT2SIRT1FOLH1 | |
| SCHEMBL8989033 | 0.82 | CTSB (0.38) | HTTLMNASMN1; SMN2L3MBTL1HSD17B10 | |
| SCHEMBL8989164 | 0.81 | BCHE (0.34) | SIRT2SIRT1HDAC3HDAC1HDAC2 | |
| SCHEMBL8988904 | 0.80 | HTT (0.47) | HTTTGM2SIRT2SIRT1FOLH1 | |
| SCHEMBL8989031 | 0.80 | HSD17B10 (0.44) | HTTTGM2SIRT2SIRT1FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488140-A | ANTICONVULSANTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5294734-A | 1-phosphato-4-amino-pent-2-enoic acids and derivatives | CIBA-GEIGY CORP. (US) | 1994-03-15 | — | — | US | disclosed |