Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.42 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.42 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8989010 | 1.00 | HTT (0.53) | HTTTGM2FOLH1KEAP1NFE2L2 | |
| SCHEMBL8989163 | 0.91 | HTT (0.50) | HTTTGM2FOLH1KEAP1NFE2L2 | |
| SCHEMBL8989159 | 0.91 | HTT (0.50) | HTTTGM2FOLH1KEAP1NFE2L2 | |
| SCHEMBL9857311 | 0.91 | HTT (0.54) | HTTTGM2FOLH1KEAP1NFE2L2 | |
| SCHEMBL9857308 | 0.91 | HTT (0.54) | HTTTGM2FOLH1KEAP1NFE2L2 | |
| SCHEMBL8988904 | 0.84 | HTT (0.47) | HTTTGM2FOLH1KEAP1NFE2L2 | |
| SCHEMBL8989017 | 0.80 | TSHR (0.36) | HTT | |
| SCHEMBL8988920 | 0.79 | HTT (0.47) | HTTTGM2FOLH1KEAP1NFE2L2 | |
| SCHEMBL8989021 | 0.77 | HTT (0.44) | HTTTGM2FOLH1SIRT2SIRT1 | |
| SCHEMBL8989007 | 0.76 | TGM2 (0.51) | HTTTGM2FOLH1KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488140-A | ANTICONVULSANTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5294734-A | 1-phosphato-4-amino-pent-2-enoic acids and derivatives | CIBA-GEIGY CORP. (US) | 1994-03-15 | — | — | US | disclosed |