Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 18/20 | 1.00 |
| ▸ | BCHE | P06276 | 11/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quilostigmine SCHEMBL8989362 | 1.00 | ACHE (1.00) | ACHEBCHEALDH1A1SMN1; SMN2NPC1 | |
| Quilostigmine SCHEMBL9150209 | 1.00 | ACHE (1.00) | ACHEBCHEALDH1A1SMN1; SMN2NPC1 | |
| Quilostigmine SCHEMBL8989327 | 1.00 | ACHE (1.00) | ACHEBCHEALDH1A1SMN1; SMN2NPC1 | |
| Quilostigmine SCHEMBL28872 | 1.00 | ACHE (1.00) | ACHEBCHEALDH1A1SMN1; SMN2NPC1 | |
| Quilostigmine SCHEMBL29868383 | 1.00 | ACHE (1.00) | ACHEBCHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL9204860 | 0.80 | ACHE (0.79) | ACHEBCHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL10109481 | 0.79 | ACHE (0.77) | ACHEBCHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL9204862 | 0.79 | ACHE (0.77) | ACHEBCHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL9204867 | 0.79 | ACHE (0.77) | ACHEBCHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8199132 | 0.79 | ACHE (0.77) | ACHEBCHEALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5498726-A | Preparation of physostigmine carbamate derivatives from physostigmine | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1996-03-12 | — | — | US | disclosed |
| US-5455354-A | Method of preparation of physostigmine carbamate derivatives from eseretholes | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1995-10-03 | — | — | US | disclosed |
| US-5302721-A | Method of preparation of physostigmine carbamate derivatives from eseretholes | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-04-12 | — | — | US | disclosed |
| EP-0581107-A1 | Method of preparation of physostigmine carbamate derivatives from eseretholes | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-02-02 | — | — | EP | disclosed |