Quilostigmine

Quilostigmine

SCHEMBL28872

CN1CC[C@@]2(C)c3cc(OC(=O)N4CCc5ccccc5C4)ccc3N(C)[C@@H]12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ACHE P22303 18/20 1.00
BCHE P06276 11/20 0.62
ALDH1A1 P00352 2/20 0.62
SMN1; SMN2 Q16637 2/20 0.62
NPC1 O15118 1/20 0.62
MAPT P10636 1/20 0.62
KDM4E B2RXH2 4/20 0.62
CYP2D6 P10635 2/20 0.62
MEN1 O00255 1/20 0.62
CYP1A2 P05177 1/20 0.62
KMT2A Q03164 1/20 0.62
HIF1A Q16665 1/20 0.62
LMNA P02545 1/20 0.62
PTGS1 P23219 1/20 0.62
OPRM1 P35372 1/20 0.62
OPRK1 P41145 1/20 0.62
BLM P54132 1/20 0.62
HRH3 Q9Y5N1 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quilostigmine SCHEMBL8989362 1.00 ACHE (1.00) ACHEBCHEALDH1A1SMN1; SMN2NPC1
Quilostigmine SCHEMBL9150209 1.00 ACHE (1.00) ACHEBCHEALDH1A1SMN1; SMN2NPC1
Quilostigmine SCHEMBL8989327 1.00 ACHE (1.00) ACHEBCHEALDH1A1SMN1; SMN2NPC1
Quilostigmine SCHEMBL8989330 1.00 ACHE (1.00) ACHEBCHEALDH1A1SMN1; SMN2NPC1
Quilostigmine SCHEMBL29868383 1.00 ACHE (1.00) ACHEBCHEALDH1A1SMN1; SMN2NPC1
SCHEMBL9204860 0.80 ACHE (0.79) ACHEBCHEALDH1A1SMN1; SMN2NPC1
SCHEMBL10109481 0.79 ACHE (0.77) ACHEBCHEALDH1A1SMN1; SMN2NPC1
SCHEMBL9204862 0.79 ACHE (0.77) ACHEBCHEALDH1A1SMN1; SMN2NPC1
SCHEMBL9204867 0.79 ACHE (0.77) ACHEBCHEALDH1A1SMN1; SMN2NPC1
SCHEMBL8199132 0.79 ACHE (0.77) ACHEBCHEALDH1A1SMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 183 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20140349976-A1 CO-ADMINISTRATION OF PIMAVANSERIN WITH OTHER AGENTS ACADIA PHARMACEUTICALS INC. (US) 2014-11-27 US claimed
WO-2011151359-A1 COMBINED TREATMENT WITH A CHOLINESTERASE INHIBITOR AND A THIADIAZOLIDINEDIONE DERIVATIVE NOSCIRA, S.A. (ES) 2011-12-08 WO claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
EP-2200610-A2 CO-ADMINISTRATION OF PIMAVANSERIN WITH OTHER AGENTS Acadia Pharmaceuticals Inc. (US) 2010-06-30 EP claimed
US-20100120747-A1 COMBINATION OF A CHOLINESTERASE INHIBITOR AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2010-05-13 US claimed
EP-2040755-A1 COMBINATION OF A CHOLINESTERASE INHIBITOR AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY Laboratorios Del. Dr. Esteve, S.A. (ES) 2009-04-01 EP claimed
WO-2009039460-A2 CO-ADMINISTRATION OF PIMAVANSERIN WITH OTHER AGENTS ACADIA PHARMACEUTICALS, INC. (US) 2009-03-26 WO claimed
WO-2009039461-A2 N-SUBSTITUTED PIPERIDINE DERIVATIVES AS SEROTONIN RECEPTOR AGENTS ACADIA PHARMACEUTICALS, INC. (US) 2009-03-26 WO claimed
US-20090082388-A1 CO-ADMINISTRATION OF PIMAVANSERIN WITH OTHER AGENTS ACADIA PHARMACEUTICALS INC. (US) 2009-03-26 US claimed
US-20080103126-A1 Medicinal compositions improving brain function and method for improving brian function TOYAMA CHEMICAL CO., LTD. (JP) 2008-05-01 US claimed
WO-2007147883-A1 COMBINATION OF A CHOLINESTERASE INHIBITOR AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2007-12-27 WO claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-20050250843-A1 Medicinal compositions improving brain function and method for improving brain function TOYAMA CHEMICAL CO., LTD. (JP) 2005-11-10 US claimed
EP-1514542-A1 MEDICINAL COMPOSITIONS IMPROVING BRAIN FUNCTION AND METHOD FOR IMPROVING BRAIN FUNCTION TOYAMA CHEMICAL CO., LTD. (JP) 2005-03-16 EP claimed
US-20030130303-A1 Pharmaceutical composition and method of treatment of diseases of cognitive dysfunction in a mammal PFIZER INC. 2003-07-10 US claimed
EP-1280554-A2 A PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT OF DISEASES OF COGNITIVE DYSFUNTION IN A MAMMAL Pfizer Products Inc. (US) 2003-02-05 EP claimed
WO-2001085145-A2 A PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT OF DISEASES OF COGNITIVE DYSFUNCTION IN A MAMMAL PFIZER PRODUCTS INC. (US) 2001-11-15 WO claimed
US-20010036949-A1 Pharmaceutical composition and method of treatment of diseases of cognitive dysfunction in a mammal PFIZER PRODUCTS INC. 2001-11-01 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140349976-A1 CO-ADMINISTRATION OF PIMAVANSERIN WITH OTHER AGENTS CHAT, ACHE, SLC18A3 ACHE 2/4885BCHE 5/4885ALDH1A1 1168/4885
US-20050250843-A1 Medicinal compositions improving brain function and method for improving brain function CHRM2, ACHE, CHAT ACHE 2/4885BCHE 18/4885ALDH1A1 1765/4885
US-20100120747-A1 COMBINATION OF A CHOLINESTERASE INHIBITOR AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY HTR6, AANAT, ACHE ACHE 3/4885BCHE 14/4885ALDH1A1 1189/4885
US-20090082388-A1 CO-ADMINISTRATION OF PIMAVANSERIN WITH OTHER AGENTS CHAT, ACHE, SLC18A3 ACHE 2/4885BCHE 5/4885ALDH1A1 1168/4885
US-20080103126-A1 Medicinal compositions improving brain function and method for improving brian function CHRM2, ACHE, CHRM1 ACHE 2/4885BCHE 4/4885ALDH1A1 1963/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.