Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8989915 | 0.83 | C5AR1 (0.51) | C5AR1THRBMCOLN3KEAP1NFE2L2 | |
| SCHEMBL8989960 | 0.80 | PSEN1 (0.50) | C5AR1THRBNPSR1MCOLN3KEAP1 | |
| SCHEMBL28858222 | 0.79 | PSEN1 (0.61) | C5AR1THRBMCOLN3KEAP1NFE2L2 | |
| SCHEMBL8989952 | 0.76 | MCOLN3 (0.50) | C5AR1THRBMCOLN3KEAP1NFE2L2 | |
| SCHEMBL8989941 | 0.76 | C5AR1 (0.53) | C5AR1THRBMCOLN3PSEN1PSEN2 | |
| SCHEMBL8990081 | 0.75 | C5AR1 (0.53) | C5AR1THRBMCOLN3PSEN1PSEN2 | |
| SCHEMBL8989867 | 0.75 | PKM (0.70) | MCOLN3KEAP1NFE2L2HCRTR2MAPT | |
| SCHEMBL30059657 | 0.73 | PSEN1 (0.45) | C5AR1THRBMCOLN3PSEN1PSEN2 | |
| SCHEMBL28927992 | 0.73 | PSEN1 (0.45) | C5AR1THRBMCOLN3PSEN1PSEN2 | |
| SCHEMBL14107556 | 0.73 | FDFT1 (0.47) | THRBNPSR1KEAP1NFE2L2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5578633-A | VASOPRESSIN AND OXYTOCIN ANTAGONISTS | SANOFI (FR) | 1996-11-26 | — | — | US | disclosed |
| US-5481005-A | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1996-01-02 | — | — | US | disclosed |
| US-5397801-A | Affinity for vasopressin and ocytocin receptors; disorders of nervous, cardiovascular and gastrointestinal systems | SANOFI (FR) | 1995-03-14 | — | — | US | disclosed |
| US-5338755-A | Have affinity for vasopressin and ocytocin receptors; intermediates for drugs that act on central nervous system | ELF SANOFI (FR) | 1994-08-16 | — | — | US | disclosed |