Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8989994 | 0.89 | MCOLN3 (0.48) | MCOLN3ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL8989902 | 0.78 | MCOLN3 (0.51) | MCOLN3ALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL8989961 | 0.76 | BDKRB1 (0.54) | ALDH1A1LMNAHPGDHTTSMN1; SMN2 | |
| SCHEMBL6608045 | 0.72 | MAPT (0.61) | ALDH1A1LMNAHPGDHTTSMN1; SMN2 | |
| SCHEMBL28858231 | 0.70 | PSEN1 (0.48) | HPGDPTGER1MEN1KMT2AKEAP1 | |
| SCHEMBL4766364 | 0.69 | MMP1 (0.48) | MCOLN3ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL5568657 | 0.69 | NR1I2 (0.65) | MCOLN3ALDH1A1LMNAPTGER1TSHR | |
| SCHEMBL8989952 | 0.69 | MCOLN3 (0.50) | MCOLN3ALDH1A1LMNAPTGER1KEAP1 | |
| SCHEMBL11141515 | 0.68 | ALDH1A1 (0.43) | ALDH1A1LMNAHPGDHTTSMN1; SMN2 | |
| SCHEMBL11141521 | 0.68 | ALDH1A1 (0.43) | ALDH1A1LMNAHPGDHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5578633-A | VASOPRESSIN AND OXYTOCIN ANTAGONISTS | SANOFI (FR) | 1996-11-26 | — | — | US | disclosed |
| US-5481005-A | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1996-01-02 | — | — | US | disclosed |
| US-5397801-A | Affinity for vasopressin and ocytocin receptors; disorders of nervous, cardiovascular and gastrointestinal systems | SANOFI (FR) | 1995-03-14 | — | — | US | disclosed |
| US-5338755-A | Have affinity for vasopressin and ocytocin receptors; intermediates for drugs that act on central nervous system | ELF SANOFI (FR) | 1994-08-16 | — | — | US | disclosed |