Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPB2 | Q96IY4 | 13/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | GHSR | Q92847 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8990122 | 1.00 | CPB2 (0.45) | CPB2MEN1KMT2ADPP7GHSR | |
| SCHEMBL29381549 | 0.99 | CPB2 (0.46) | CPB2MEN1KMT2ADPP7GHSR | |
| SCHEMBL8729043 | 0.99 | CPB2 (0.46) | CPB2MEN1KMT2ADPP7GHSR | |
| SCHEMBL29630532 | 0.94 | NMT1 (0.45) | CPB2MEN1KMT2ADPP7GHSR | |
| SCHEMBL23303426 | 0.94 | MEN1 (0.48) | CPB2MEN1KMT2ADPP7GHSR | |
| SCHEMBL29578895 | 0.94 | MEN1 (0.48) | CPB2MEN1KMT2ADPP7GHSR | |
| SCHEMBL29470578 | 0.94 | MEN1 (0.48) | CPB2MEN1KMT2ADPP7GHSR | |
| SCHEMBL23303428 | 0.94 | MEN1 (0.48) | CPB2MEN1KMT2ADPP7GHSR | |
| SCHEMBL14906323 | 0.94 | MEN1 (0.48) | CPB2MEN1KMT2ADPP7GHSR | |
| SCHEMBL18075734 | 0.94 | MEN1 (0.48) | CPB2MEN1KMT2ADPP7GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721447-A1 | ANTHRACENE DERIVATIVES FOR USE AS ANTICANCER AGENT OR DYE | NAPIER UNIVERSITY VENTURES LIMITED (GB) | 1996-07-17 | — | — | EP | disclosed |