Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.71 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.59 |
| ▸ | TMIGD3 | P0DMS9 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5471522 | 0.98 | APP (0.69) | APPADORA1ADORA2AADORA2BADORA3 | |
| Sulfuric Acid SCHEMBL5463730 | 0.91 | APP (0.61) | APPADORA1ADORA2AADORA2BADORA3 | |
| SCHEMBL22151175 | 0.85 | APP (0.64) | APPADORA1ADORA2AADORA2BADORA3 | |
| SCHEMBL2451092 | 0.84 | APP (0.64) | APPADORA1ADORA2AADORA2BADORA3 | |
| SCHEMBL8990761 | 0.83 | APP (0.51) | APPADORA1ADORA2AADORA2BADORA3 | |
| SCHEMBL5458920 | 0.82 | APP (0.62) | APPADORA1ADORA2AADORA2BADORA3 | |
| Hydrochloric Acid SCHEMBL5478228 | 0.81 | APP (0.67) | APPADORA1ADORA2AADORA2BADORA3 | |
| SCHEMBL8990551 | 0.79 | ADORA3 (0.61) | APPADORA1ADORA2AADORA2BADORA3 | |
| SCHEMBL9792866 | 0.78 | APP (0.57) | APPADORA1ADORA2AADORA2BADORA3 | |
| SCHEMBL21055814 | 0.78 | APP (0.68) | APPADORA1ADORA2AADORA2BADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500428-A | Furyl-substituted purines and adenosine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-03-19 | — | — | US | disclosed |
| US-5300509-A | Adenosine antagonists for treating cardiovascular disorders, vasodilation | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-04-05 | — | — | US | disclosed |
| EP-0544445-A2 | Furyl-substituted purines, oxazolopyrimidines and pteridines as adenosine antagonists | ZENECA LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |