Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.51 |
| ▸ | GALR3 | O60755 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 7/20 | 0.47 |
| ▸ | CA2 | P00918 | 7/20 | 0.47 |
| ▸ | CA9 | Q16790 | 7/20 | 0.47 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990589 | 0.83 | APP (0.71) | APPADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL8990551 | 0.83 | ADORA3 (0.61) | APPADORA2AADORA1ADORA2BADORA3 | |
| Hydrochloric Acid SCHEMBL5471522 | 0.81 | APP (0.69) | APPADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL8990782 | 0.76 | LMNA (0.71) | APPADORA2AADORA1ADORA2BADORA3 | |
| Sulfuric Acid SCHEMBL5463730 | 0.75 | APP (0.61) | APPADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL5161863 | 0.74 | ADORA2A (0.68) | ADORA2AADORA1ADORA2BADORA3TMIGD3 | |
| SCHEMBL4373125 | 0.70 | HTR7 (0.74) | CA1CA2CA9ADRA1DHTR2C | |
| SCHEMBL24756902 | 0.70 | MAPT (0.65) | APPGALR3CA1CA2CA9 | |
| SCHEMBL26267841 | 0.70 | MAPT (0.65) | APPGALR3CA1CA2CA9 | |
| SCHEMBL8547756 | 0.70 | APP (0.76) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500428-A | Furyl-substituted purines and adenosine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-03-19 | — | — | US | disclosed |
| US-5300509-A | Adenosine antagonists for treating cardiovascular disorders, vasodilation | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-04-05 | — | — | US | disclosed |
| EP-0544445-A2 | Furyl-substituted purines, oxazolopyrimidines and pteridines as adenosine antagonists | ZENECA LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |