Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990578 | 0.81 | RAB9A (0.53) | KDM4EHPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14552907 | 0.66 | EGLN1 (0.44) | KDM4EHPGDSMN1; SMN2RAB9ATP53 | |
| SCHEMBL655417 | 0.66 | RAB9A (0.51) | KDM4ESMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL8990610 | 0.65 | NPC1 (0.52) | KDM4ESMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL6632968 | 0.65 | RAB9A (1.00) | KDM4EHPGDSMN1; SMN2RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL1832732 | 0.65 | NPC1 (0.53) | KDM4ESMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL27954065 | 0.65 | MAPK1 (0.44) | TP53MAPTPOLB | |
| SCHEMBL8990595 | 0.64 | RAB9A (0.50) | KDM4EHPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5692749 | 0.64 | NPC1 (0.52) | KDM4EHPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5692659 | 0.63 | HSD17B10 (0.68) | KDM4EHPGDSMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500428-A | Furyl-substituted purines and adenosine antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-03-19 | — | — | US | disclosed |
| US-5300509-A | Adenosine antagonists for treating cardiovascular disorders, vasodilation | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-04-05 | — | — | US | disclosed |
| EP-0544445-A2 | Furyl-substituted purines, oxazolopyrimidines and pteridines as adenosine antagonists | ZENECA LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |