Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 4/20 | 0.58 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 5/20 | 0.36 |
| ▸ | DRD4 | P21917 | 5/20 | 0.36 |
| ▸ | DRD3 | P35462 | 5/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8991111 | 0.93 | GHSR (0.57) | GHSRAGTR1TACR1OPRM1OPRD1 | |
| SCHEMBL8990729 | 0.92 | GHSR (0.57) | GHSRAGTR1TACR1OPRM1OPRD1 | |
| SCHEMBL8990829 | 0.92 | GHSR (0.52) | GHSRAGTR1TACR1OPRM1DRD2 | |
| SCHEMBL8990939 | 0.92 | GHSR (0.68) | GHSRAGTR1TACR1OPRM1OPRD1 | |
| SCHEMBL8990838 | 0.91 | GHSR (0.51) | GHSRAGTR1TACR1DRD2DRD4 | |
| SCHEMBL8990944 | 0.91 | GHSR (0.51) | GHSRAGTR1TACR1OPRM1OPRD1 | |
| SCHEMBL8990960 | 0.91 | GHSR (0.47) | GHSRAGTR1TACR1OPRM1OPRD1 | |
| SCHEMBL8991136 | 0.89 | GHSR (0.46) | GHSRAGTR1TACR1OPRM1OPRD1 | |
| SCHEMBL8990953 | 0.89 | GHSR (0.51) | GHSRAGTR1TACR1OPRM1OPRD1 | |
| SCHEMBL8991059 | 0.88 | GHSR (0.50) | GHSRAGTR1TACR1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545735-A | ANIMAL GROWTH REGULATORS | MERCK & CO., INC. (US) | 1996-08-13 | — | — | US | claimed |
| US-5545735-A | ANIMAL GROWTH REGULATORS | MERCK & CO., INC. (US) | 1996-08-13 | — | — | US | disclosed |
| WO-1995009633-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-04-13 | — | — | WO | disclosed |