Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
| ▸ | PDE1A | P54750 | 2/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8991412 | 0.89 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8991245 | 0.85 | SRC (0.40) | EGFRSRCCYP11B1CYP11B2TSHR | |
| SCHEMBL8991388 | 0.85 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8991063 | 0.82 | GAA (0.41) | PDE4APDE4BPDE4CPDE4DEGFR | |
| SCHEMBL8991419 | 0.80 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8991237 | 0.80 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8991296 | 0.78 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8991141 | 0.78 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DEGFR | |
| SCHEMBL8991138 | 0.77 | ABL1 (0.43) | PDE4APDE4BPDE4CPDE4DAURKA | |
| SCHEMBL8990926 | 0.75 | EGFR (0.32) | EGFRSRCYTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5543413-A | VIRAL ACTIVITY AGAINST HUMAN CYTOMEGALOVIRUS AND HERPES SIMPLEX VIRUS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1996-08-06 | — | — | US | disclosed |