Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 7/20 | 0.94 |
| ▸ | CA1 | P00915 | 2/20 | 0.94 |
| ▸ | CA4 | P22748 | 2/20 | 0.94 |
| ▸ | CA6 | P23280 | 2/20 | 0.94 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.94 |
| ▸ | CA2 | P00918 | 1/20 | 0.94 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.94 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.94 |
| ▸ | ITGAL | P20701 | 1/20 | 0.94 |
| ▸ | ADK | P55263 | 1/20 | 0.94 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indole SCHEMBL17515233 | 1.00 | AHR (0.94) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL9392663 | 0.97 | AHR (0.90) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL28071644 | 0.97 | AHR (1.00) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL29352896 | 0.97 | — | — | |
| Indole SCHEMBL698 | 0.97 | — | — | |
| Indole SCHEMBL30250492 | 0.97 | — | — | |
| Indole SCHEMBL1160186 | 0.97 | AHR (1.00) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL30463845 | 0.97 | — | — | |
| Indole SCHEMBL23886438 | 0.94 | AHR (0.94) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL7004015 | 0.94 | AHR (0.94) | AHRCA1CA4CA6TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111303117-B | Preparation method of nitrogen heterocyclic ring substituted indole thioether compound | 常州工程职业技术学院 | 2021-09-07 | — | — | CN | claimed |
| CN-111303117-A | Preparation method of nitrogen heterocyclic ring substituted indole thioether compound | 常州工程职业技术学院 | 2020-06-19 | — | — | CN | claimed |
| CN-113234007-B | Synthesis method of 4-indolylthiobutanoic acid derivative | 四川轻化工大学 | 2022-10-25 | — | — | CN | disclosed |
| CN-111303117-B | Preparation method of nitrogen heterocyclic ring substituted indole thioether compound | 常州工程职业技术学院 | 2021-09-07 | — | — | CN | disclosed |
| CN-111303117-B | Preparation method of nitrogen heterocyclic ring substituted indole thioether compound | 常州工程职业技术学院 | 2021-09-07 | — | — | CN | disclosed |
| CN-111303117-B | Preparation method of nitrogen heterocyclic ring substituted indole thioether compound | 常州工程职业技术学院 | 2021-09-07 | — | — | CN | disclosed |
| CN-113234007-A | Synthesis method of 4-indolylthiobutyric acid derivative | 四川轻化工大学 | 2021-08-10 | — | — | CN | disclosed |
| EP-3180420-B1 | BACTERIUM OF BACILLUS SUBTILIS SSP. SHRIRAMENSIS AND USES THEREOF | DCM SHRIRAM LTD (IN) | 2020-10-21 | — | — | EP | disclosed |
| CN-111303117-A | Preparation method of nitrogen heterocyclic ring substituted indole thioether compound | 常州工程职业技术学院 | 2020-06-19 | — | — | CN | disclosed |
| CN-111303117-A | Preparation method of nitrogen heterocyclic ring substituted indole thioether compound | 常州工程职业技术学院 | 2020-06-19 | — | — | CN | disclosed |
| CN-111303117-A | Preparation method of nitrogen heterocyclic ring substituted indole thioether compound | 常州工程职业技术学院 | 2020-06-19 | — | — | CN | disclosed |
| US-6916841-B2 | Inhibitors of phospholipase enzymes | GENETICS INSTITUTE, LLC (US) | 2005-07-12 | — | — | US | disclosed |
| US-6828344-B1 | Direct inhibition of the activity of phospholipase A2 has been suggested as a useful mechanism for a therapeutic agent for inflammation | GENETICS INSTITUTE, LLC | 2004-12-07 | — | — | US | disclosed |
| US-20030153751-A1 | Inhibitors of phospholipase enzymes | AMERICAN HOME PRODUCTS CORPORATION | 2003-08-14 | — | — | US | disclosed |
| US-6500853-B1 | ENZYME INHIBITORS SUCH AS 4-((1-BENZHYDRYL-5-(((BUTYLAMINO)-CARBONYL)AMINO)-1H-INDOL-3-YL)METHYL)-3 -METHOXYBENZOIC ACID USED AS ANTIINFLAMMATORY AGENTS FOR PROPHYLAXIS OF ARTHRITIS, INFLAMMATORY BOWEL DISEASE OR ASTHMA | GENETICS INSTITUTE, LLC | 2002-12-31 | — | — | US | disclosed |
| EP-1062205-A2 | INHIBITORS OF PHOSPHOLIPASE ENZYMES | GENETICS INSTITUTE, INC. (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-1056719-A2 | INHIBITORS OF PHOSPHOLIPASE ENZYMES | GENETICS INSTITUTE, INC. (US) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999043654-A2 | INHIBITORS OF PHOSPHOLIPASE ENZYMES | GENETICS INSTITUTE, INC. (US) | 1999-09-02 | — | — | WO | disclosed |
| WO-1999043651-A2 | INHIBITORS OF PHOSPHOLIPASE ENZYMES | GENETICS INSTITUTE, INC. (US) | 1999-09-02 | — | — | WO | disclosed |
| US-5059444-A | Dispersing red pigment; heating to discolor and sterilize | ITO HAM KABUSHIKI KAISHA (JP) | 1991-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153751-A1 | Inhibitors of phospholipase enzymes | PLA2G4C, PLA2G4B, PLA2G4A | AHR 4427/4885CA1 1996/4885CA4 2960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.