Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.64 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | PNP | P00491 | 1/20 | 0.58 |
| ▸ | MPO | P05164 | 2/20 | 0.52 |
| ▸ | TPO | P07202 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10978398 | 0.93 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL1461291 | 0.86 | MPO (0.70) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL1460900 | 0.80 | MPO (0.69) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL5515323 | 0.78 | ADORA2A (0.71) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7466316 | 0.78 | ADORA2A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7029046 | 0.78 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7345938 | 0.77 | PDE5A (0.66) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL6141778 | 0.77 | ADORA2A (0.64) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Enprofylline SCHEMBL1817246 | 0.76 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Enprofylline SCHEMBL156402 | 0.76 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510561-B1 | Oral, cutaneous and intravaginal pharmaceutical compositions in the form of foam | POLI IND CHIMICA SPA (IT) | 1996-07-24 | — | — | EP | claimed |
| US-5369131-A | Oral, cutaneous and intravaginal pharmaceutical compositions in the form of foam | POLI INDUSTRIA CHIMICA S.P.A. (IT) | 1994-11-29 | — | — | US | claimed |
| EP-0510561-A1 | Oral, cutaneous and intravaginal pharmaceutical compositions in the form of foam | POLI INDUSTRIA CHIMICA S.p.A. (IT) | 1992-10-28 | — | — | EP | claimed |
| JP-3200787-A | — | — | None | — | — | JP | disclosed |
| JP-H03200787-A | XANTHINE DERIVATIVE, PROCESS FOR THE PREPARATION THEREOF AND BRONCHODILATOR CONTAINING IT | POLI IND CHIM SPA | 1991-09-02 | — | — | JP | disclosed |
| EP-0386683-A2 | Xanthine derivatives having bronchodilating activity, a process for the preparation thereof and pharmaceutical compositions containing them | POLI INDUSTRIA CHIMICA S.p.A. (IT) | 1990-09-12 | — | — | EP | disclosed |