Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Tetrydamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | INMT | O95050 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrydamine SCHEMBL43249 | 0.85 | GAA (1.00) | GAAMEN1KMT2APOLBCYP1A2 | |
| SCHEMBL4770442 | 0.70 | POLB (1.00) | GAAMEN1KMT2APOLBCYP1A2 | |
| SCHEMBL24405748 | 0.69 | POLB (0.96) | GAAMEN1KMT2APOLBCYP1A2 | |
| SCHEMBL16739580 | 0.69 | POLB (0.62) | GAAMEN1KMT2APOLBCYP1A2 | |
| SCHEMBL9988831 | 0.69 | GAA (0.62) | GAAMEN1KMT2APOLBCYP1A2 | |
| SCHEMBL13145631 | 0.67 | GAA (0.65) | GAAMEN1KMT2APOLBCYP1A2 | |
| SCHEMBL17324712 | 0.67 | POLB (0.74) | GAAMEN1KMT2APOLBCYP1A2 | |
| SCHEMBL23062881 | 0.67 | POLB (0.93) | GAAMEN1KMT2APOLBCYP1A2 | |
| SCHEMBL5067149 | 0.66 | POLB (0.72) | GAAMEN1KMT2APOLBCYP1A2 | |
| SCHEMBL16144859 | 0.66 | MAPT (0.72) | GAAMEN1KMT2APOLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510561-B1 | Oral, cutaneous and intravaginal pharmaceutical compositions in the form of foam | POLI IND CHIMICA SPA (IT) | 1996-07-24 | — | — | EP | disclosed |
| US-5369131-A | Oral, cutaneous and intravaginal pharmaceutical compositions in the form of foam | POLI INDUSTRIA CHIMICA S.P.A. (IT) | 1994-11-29 | — | — | US | disclosed |
| EP-0510561-A1 | Oral, cutaneous and intravaginal pharmaceutical compositions in the form of foam | POLI INDUSTRIA CHIMICA S.p.A. (IT) | 1992-10-28 | — | — | EP | disclosed |