SCHEMBL8991983

SCHEMBL8991983

CCOC(=O)c1cccc([N+](=O)[O-])c1F

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.54
SMN1; SMN2 Q16637 4/20 0.54
GAA P10253 2/20 0.54
TSHR P16473 2/20 0.53
MAPT P10636 6/20 0.51
LMNA P02545 3/20 0.49
NPSR1 Q6W5P4 2/20 0.49
GALR2 O43603 1/20 0.49
MITF O75030 1/20 0.49
POLB P06746 1/20 0.49
HSP90AA1 P07900 1/20 0.49
HPGD P15428 1/20 0.49
XBP1 P17861 1/20 0.49
CCR6 P51684 1/20 0.49
HSD17B10 Q99714 1/20 0.46
CACNA1C Q13936 1/20 0.46
MAPK1 P28482 2/20 0.46
KMT2A Q03164 2/20 0.46
MEN1 O00255 1/20 0.46
HTT P42858 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29738072 0.87 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL3481205 0.85 TSHR (0.64) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL1523174 0.84 ALDH1A1 (0.67) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL7860227 0.84 ALDH1A1 (0.44) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL1611630 0.84 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL22391679 0.84 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL11464655 0.84 ALDH1A1 (0.57) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL960443 0.83 TSHR (0.53) ALDH1A1SMN1; SMN2TSHRMAPTLMNA
SCHEMBL2977262 0.82 ALDH1A1 (0.54) ALDH1A1SMN1; SMN2GAATSHRMAPT
SCHEMBL5752237 0.82 ALDH1A1 (0.54) ALDH1A1SMN1; SMN2GAATSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110105340-A Benzamide and nicotinamide compounds and its application method 昂康塔睿迪斯股份有限公司 2019-08-09 CN disclosed
CN-110016015-A Benzamide and nicotinamide compounds and its application method 昂康塔睿迪斯股份有限公司 2019-07-16 CN disclosed
CN-104640846-A Benzimidazole-carboxylic acid amide derivatives as APJ receptor modulators SANOFI SA 2015-05-20 CN disclosed
US-5543550-A NITRATING ALKYL ESTER OF 3-FLUOROBENZOIC ACID DISSOLVED IN SOLVENT-FREE SULFURIC ACID, THEN ADDING WATER, SEPARATION, HYDROLYSIS, PRESSURIZED CATALYTIC HYDROGENATION OF THE NITRATED ACID HOECHST AKTIENGESELLSCHAFT (DE) 1996-08-06 US disclosed