Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Fumarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 known ✓ | Q14145 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.83 |
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 5/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2302656 | 1.00 | ATM (0.83) | ATMHCAR2MAPTRAB9ANPSR1 | |
| Dimethyl Maleate SCHEMBL8992612 | 1.00 | ATM (0.83) | ATMHCAR2MAPTRAB9ANPSR1 | |
| SCHEMBL2302660 | 1.00 | ATM (0.83) | ATMHCAR2MAPTRAB9ANPSR1 | |
| SCHEMBL555290 | 1.00 | ATM (0.83) | ATMHCAR2MAPTRAB9ANPSR1 | |
| SCHEMBL22619937 | 0.96 | ATM (0.77) | ATMHCAR2MAPTRAB9ANPSR1 | |
| SCHEMBL10389785 | 0.94 | ATM (0.73) | ATMHCAR2MAPTRAB9ANPSR1 | |
| SCHEMBL554181 | 0.94 | ATM (0.73) | ATMHCAR2MAPTRAB9ANPSR1 | |
| Monomethyl Fumarate SCHEMBL28123679 | 0.93 | HCAR2 (0.86) | ATMHCAR2MAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL9358646 | 0.93 | HCAR2 (0.86) | ATMHCAR2MAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL9358650 | 0.93 | HCAR2 (0.86) | ATMHCAR2MAPTRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397122-B1 | Olefin polymerization catalyst and process for producing ethylene copolymers | SUMITOMO CHEMICAL CO (JP) | 1996-08-07 | — | — | EP | disclosed |
| US-5166280-A | Olefin polymerization catalyst and process for producing ethylene copolymers | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1992-11-24 | — | — | US | disclosed |
| US-5077250-A | OLEFIN POLYMERIZATION CATALYST AND PROCESS FOR PRODUCING ETHYLENE COPOLYMERS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1991-12-31 | — | — | US | disclosed |
| EP-0397122-A2 | Olefin polymerization catalyst and process for producing ethylene copolymers | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1990-11-14 | — | — | EP | disclosed |