Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Butyl Fumarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 known ✓ | Q14145 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 8/20 | 0.86 |
| ▸ | ATM | Q13315 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyl Fumarate SCHEMBL9358650 | 1.00 | HCAR2 (0.86) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Monomethyl Fumarate SCHEMBL28123679 | 1.00 | HCAR2 (0.86) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL1655582 | 0.93 | HCAR2 (0.92) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL27358297 | 0.93 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL124163 | 0.93 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL4376900 | 0.93 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL43165 | 0.93 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL43164 | 0.93 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Maleic Acid SCHEMBL28199237 | 0.93 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL29604195 | 0.93 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0285140-B1 | Process for producing toner for developing electrostatic images | CANON KK (JP) | 1994-12-21 | — | — | EP | disclosed |
| US-4839255-A | IMPACTING MODIFIER TO BASE PARTICLES | CANON KABUSHIKI KAISHA (JP) | 1989-06-13 | — | — | US | disclosed |
| EP-0285140-A2 | Process for producing toner for developing electrostatic images | CANON KABUSHIKI KAISHA (JP) | 1988-10-05 | — | — | EP | disclosed |