SCHEMBL8992939

SCHEMBL8992939

CCOC(=O)c1ccc(C=O)c(OC)c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B2 P37059 1/20 0.66
LMNA P02545 2/20 0.53
NPC1 O15118 2/20 0.52
RAB9A P51151 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
CA12 O43570 2/20 0.51
CA1 P00915 2/20 0.51
CA2 P00918 2/20 0.51
CA7 P43166 2/20 0.51
CA9 Q16790 2/20 0.51
CA14 Q9ULX7 2/20 0.51
KDM4E B2RXH2 3/20 0.51
POLB P06746 1/20 0.51
ALDH1A1 P00352 5/20 0.50
MAPT P10636 5/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
TSHR P16473 1/20 0.50
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
ERN1 O75460 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15322138 0.88 HSD17B2 (0.54) HSD17B2LMNANPC1RAB9ASMN1; SMN2
SCHEMBL1353939 0.88 HSD17B2 (0.61) HSD17B2LMNANPC1RAB9ASMN1; SMN2
SCHEMBL10948571 0.85 HSD17B2 (0.62) HSD17B2LMNANPC1RAB9ASMN1; SMN2
SCHEMBL10941898 0.85 HSD17B2 (0.58) HSD17B2LMNANPC1RAB9ASMN1; SMN2
SCHEMBL10941886 0.85 HSD17B2 (0.58) HSD17B2LMNANPC1RAB9ASMN1; SMN2
SCHEMBL498854 0.84 ALDH1A1 (0.53) HSD17B2LMNANPC1RAB9ASMN1; SMN2
SCHEMBL644569 0.84 MAPT (0.63) LMNANPC1RAB9ASMN1; SMN2CA12
SCHEMBL16528001 0.83 HSD17B2 (0.49) HSD17B2LMNANPC1RAB9ASMN1; SMN2
SCHEMBL28343239 0.83 HSD17B2 (0.49) HSD17B2LMNANPC1RAB9ASMN1; SMN2
SCHEMBL28343131 0.83 HSD17B2 (0.49) HSD17B2LMNANPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118580016-A Nicotinamide ribochlorate-based salicylaldehyde functional molecule hybridized natural brucite-based composite powder, and preparation method and application thereof 江西广源化工有限责任公司 2024-09-03 CN disclosed
US-5516777-A PROSTATE CANCER THERAPY OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1996-05-14 US disclosed
US-5409928-A Prostate diseases, alopecia OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1995-04-25 US disclosed
EP-0594149-A2 Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-04-27 EP disclosed