Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.41 |
| ▸ | HRH1 | P35367 | 7/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | UBE2M | P61081 | 1/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8992978 | 0.80 | MAOB (0.42) | SIGMAR1KMT2APBRM1MAOB | |
| SCHEMBL107889 | 0.79 | HRH1 (0.56) | HTR2AHRH1SIGMAR1KMT2AAOC3 | |
| SCHEMBL19113570 | 0.77 | ESR1 (0.46) | KMT2AUBE2MDCUN1D1DRD3ADRA2A | |
| Hydrochloric Acid SCHEMBL6521685 | 0.77 | HRH1 (0.54) | HTR2AHRH1SIGMAR1KMT2AAOC3 | |
| Hydrogen Peroxide SCHEMBL27864054 | 0.77 | HRH1 (0.54) | HTR2AHRH1SIGMAR1KMT2AAOC3 | |
| Ammonia Solution, Strong SCHEMBL5724927 | 0.77 | HRH1 (0.54) | HTR2AHRH1SIGMAR1KMT2AAOC3 | |
| SCHEMBL28229621 | 0.77 | HRH1 (0.54) | HTR2AHRH1SIGMAR1KMT2AAOC3 | |
| SCHEMBL8992781 | 0.77 | HTR2A (0.44) | HTR2AHRH1SIGMAR1KMT2ACYP19A1 | |
| SCHEMBL10585427 | 0.77 | TSHR (0.45) | KMT2APBRM1LMNA | |
| SCHEMBL10567235 | 0.77 | TRPA1 (0.45) | HTR2AKMT2APBRM1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |