Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8992953 | 0.91 | HSD17B2 (0.56) | HSD17B2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL8992796 | 0.84 | HSD17B2 (0.59) | HSD17B2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL8992942 | 0.81 | HSD17B2 (0.56) | HSD17B2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6929080 | 0.76 | HSD17B2 (0.59) | HSD17B2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL1660365 | 0.76 | HSD17B2 (0.76) | HSD17B2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL30506315 | 0.76 | HSD17B2 (0.76) | HSD17B2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL8133666 | 0.75 | HSD17B2 (0.58) | HSD17B2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL310621 | 0.75 | TSHR (0.71) | HSD17B2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL31474384 | 0.75 | TSHR (0.71) | HSD17B2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL27603935 | 0.75 | HSD17B2 (0.69) | HSD17B2NPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |