Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA7 | P43166 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8133666 | 0.88 | HSD17B2 (0.58) | HSD17B2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL20768595 | 0.85 | CA1 (0.50) | HSD17B2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL19347921 | 0.85 | CA1 (0.50) | HSD17B2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL30040313 | 0.82 | CA1 (0.48) | HSD17B2RAB9ASMN1; SMN2KDM4ECA1 | |
| SCHEMBL20768660 | 0.82 | CA1 (0.48) | HSD17B2RAB9AKDM4ECA1CA2 | |
| SCHEMBL19347288 | 0.82 | CA1 (0.48) | HSD17B2RAB9AKDM4ECA1CA2 | |
| SCHEMBL20768545 | 0.82 | CA1 (0.48) | HSD17B2RAB9ASMN1; SMN2KDM4ECA1 | |
| SCHEMBL19347437 | 0.82 | CA1 (0.48) | HSD17B2RAB9ASMN1; SMN2KDM4ECA1 | |
| SCHEMBL8992796 | 0.78 | HSD17B2 (0.59) | HSD17B2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL30506315 | 0.78 | HSD17B2 (0.76) | HSD17B2NPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010056211-A1 | Guaiacoxypropanolamines with alpha/beta adrenergic blocking activity | NATIONAL SCIENCE COUNCIL (TW) | 2001-12-27 | — | — | US | claimed |
| US-6518450-B2 | Adrenergic blocking agent | NATIONAL SCIENCE COUNCIL (TW) | 2003-02-11 | — | — | US | disclosed |
| US-20010056211-A1 | Guaiacoxypropanolamines with alpha/beta adrenergic blocking activity | NATIONAL SCIENCE COUNCIL (TW) | 2001-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010056211-A1 | Guaiacoxypropanolamines with alpha/beta adrenergic blocking activity | ADRB1, ADRA1A, ADRA1B | HSD17B2 470/4885NPC1 1185/4885RAB9A 782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.